Series A AI safety / red-teaming founded 2024 · 30-60 people · Pittsburgh, PA
ai ml security enterprise
AI security platform built around automated red-teaming of frontier models — runtime guardrails, continuous adversarial testing, and the published Cygnet benchmark. CMU spinout cited in Anthropic, OpenAI, and Meta safety reports.
Latest round: $40M Series A (May 2026) · led by Wing Venture Capital, Madrona, Obvious Ventures, +4 more · $50M total raised
Founders: Matt Fredrikson, Zico Kolter
Leadership: Matt Fredrikson (CEO), Zico Kolter (Chief Scientist)
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seed Geospatial / civil engineering AI founded 2022 · 30-60 people · Pittsburgh, PA
ai ml robotics data
AI-native CAD platform for civil engineering — turns mobile-LiDAR scans and image data into 2D/3D engineering models 30x faster than traditional manual survey processing. CMU Robotics Institute spinout; Liberty Avenue HQ in Pittsburgh.
Latest round: $14.4M Seed (Mar 2026) · led by Y Combinator, Kyle Vogt, Amar Hanspal
Founders: Alexander Baikovitz, Haowen Shi, Josh Spisak
Leadership: Alexander Baikovitz (CEO)
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pre-seed Remote auscultation founded 2023 · 5-15 people · Pittsburgh, PA
healthtech ai ml hardware
Guided home electronic stethoscope — an AI-coached recording app paired with a low-cost scope that lets a patient capture clinician-readable heart and lung audio at home. Pitt School of Medicine spinout; won the 2024 Hult Prize; AlphaLab 2026 cohort.
Latest round: $100K Pre-Seed (Feb 2026) · led by AlphaLab · $2.3M total raised
Founders: Anna Li
Leadership: Anna Li (CEO)
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may be inactive — last checked Jun 2026
Series A Underground mining AI founded 2015 · 30-60 people · Pittsburgh, PA
ai ml robotics data
Vision-driven 3D mapping and analytics for underground mining — FaceCapture builds real-time geometry of an active face from a worker-carried scanner. Spun out of CMU's NREC; expanding Pittsburgh workforce after the late-2025 Series A.
Latest round: $12.5M Series A (Nov 2025) · led by Rockwell Venture Capital, Condire Investors
Founders: Michael Smocer
Leadership: Michael Smocer (CEO)
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Series A Community small-business lending founded 2017 · 20-50 people · Pittsburgh, PA
fintech saas
Crowdfunded small-business loans — local lenders fund local businesses via investment notes. Pittsburgh-HQ fintech.
Latest round: $6M Series A (Jun 2024)
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Series A Customer-data AI founded 2016 · 30-60 people · Pittsburgh, PA
ai ml data saas
Customer-data AI platform for utilities and financial services — clusters end-customers and predicts behavior (program enrollment, churn, payment risk) from unified billing + demographic data. Born out of CMU's CONNECTS program; East Liberty HQ.
Latest round: $14.2M Series A (Apr 2024) · led by Top Tier Capital Partners · $24M total raised
Founders: Alison Alvarez, Tomer Borenstein
Leadership: Alison Alvarez (CEO), Tomer Borenstein (CTO)
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seed Clinical workflow tools founded 2020 · 10-30 people · Pittsburgh, PA
healthtech mobile-ios hardware
Nurse-founded clinical tools — hands-free task light plus a workforce marketplace app that pairs nurses with hospital shifts. Y Combinator alum; small bootstrapped-after-seed Pittsburgh team.
Latest round: $1.2M Seed (Jun 2023) · led by Y Combinator, Flare Capital, Fresco Capital, +1 more
Founders: Jennifferre Mancillas, Anthony Scarpone-Lambert
Leadership: Jennifferre Mancillas (CEO)
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may be inactive — last checked Jun 2026
Series A Autonomous aircraft systems founded 2011 · 50-100 people · Pittsburgh, PA
robotics aviation ai
Develops autonomy systems — sensing, mapping, and flight software — that let aircraft and large drones inspect, deliver, and land without a pilot. CMU Robotics Institute spinout headquartered in Pittsburgh.
Latest round: $6M Series A (Jan 2023)
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seed Network performance monitoring founded 2013 · 10-30 people · Pittsburgh, PA
saas devops enterprise
Distributed network and digital-experience monitoring — physical and virtual agents scattered across an enterprise's offices detect SaaS, Wi-Fi, and ISP problems from the user's end of the wire. Y Combinator '15 alum; small, lean, long-bootstrapped Pittsburgh team.
Latest round: $1.3M Seed (Sep 2015) · led by Y Combinator
Founders: Stefano Gridelli, Panos Vouzis
Leadership: Stefano Gridelli (CEO)
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may be inactive — last checked Jun 2026
Series A Anti-trafficking analytics founded 2014 · 20-50 people · Pittsburgh, PA
ai ml saas data
Traffic Jam platform — online-data analytics for human-trafficking investigations. Used by law enforcement worldwide; CMU spinout led by a former Carnegie Mellon researcher.
Founders: Cara Jones, Emily Kennedy